There are basic facts that should be learnt about the use of these meds with PCOS (polycystic ovarian syndrome). Those women who don’t ovulate often have this medical condition, and they are prescribed to take Clomid, which is the most popular medication taken to induce ovulation. When it comes to Metformin, this medicine is prescribed to treat diabetes, but it can be used with PCOS to help female patients achieve pregnancy.

Effects of Taking Metformin and Clomid

In rare cases, those women who don’t ovulate on a regular basis and have PCOS can become pregnant after taking Metformin alone. If this effect is not achieved, they are advised to add Clomid to their treatment. Combined intake of both meds proves to be quite beneficial for women with this health condition. If they succeed to get pregnant when undergoing this treatment, they can avoid more invasive and expensive treatment options, including in-vitro fertilization.

Side Effects of These Meds

About ¼ of all female patients who take Metformin end up with certain gastrointestinal adverse effects, including nausea, abdominal pain, diarrhea and others, but there are no severe symptoms reported. The use of Clomid is also associated with mild and moderate side effects.

Correct Dosages

First, women with polycystic ovaries should understand that the benefits of taking Metformin for ovulation are not seen at once. This means that this medicine should be taken at least for 2-3 months to become fertile, and it’s necessary to take Metformin in those doses that they can tolerate. Most patients can tolerate up to 500 mg taken 3 times a day, but their doses should be increased gradually. Their treatment should start with 500 mg taken once a day, then it must be increased to 500 mg taken twice a day, and they can increase this dose after once week. If women can’t tolerate this dosage because of obvious adverse effects, they should stick to taking Metformin only twice a day.

The initial dose of Clomid is one pill that contains 50 mg taken each during 5 days, and it’s required to start this treatment in women’s menstrual cycle. If they have irregular cycles, they need to have their periods induced with some effective progestin medications. If 50 mg of Clomid taken once a day doesn’t result in ovulation, it’s advisable to increase this dosage up to 100 mg in the next cycle. If this step doesn’t help women, they can try 150 mg before they give up on this medicine and try other available treatment options.

Success Rates of Both Meds

It’s a bit difficult to give success rates for Clomid and Metformin for PCOS, and the main reason is that every case is individual, and there are many factors that may affect women’s chances for success, including their weight, age, fertility issues, sperm parameters and so on. However, when treating women who are under 37 years old, with ovulation, and normal sperm, it’s possible to expect such pregnancy rates as 10-15% for both medications compared to 15-20% of IUI. Doctors expect these success rates to hold up for around 3 months, and any further attempts beyond that are associated with lower chances to succeed. In conclusion, if the intake of Clomid and Metformin doesn’t help women with PCOS to become pregnant, they can try more aggressive options, such as IVF, Femara and others, but they need to consult their doctors before making any final decision.